Documentation:Nightly:Registration:RegistrationLibrary:RegLib C42

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Slicer Registration Library Case #42:
Intra-subject Brain MRI: serial assessment of brain development in autism

Input

fixed image/target		moving image

Description

This is a typical case of change assessment.

*RegLib_C42.mrb 
(input data only, Slicer mrb file. 12 MB) 

• RegLib_C42_full.mrb
  (input data + results, Slicer mrb file. 36 MB).

Keywords

MRI, brain, head, intra-subject, T1, autism, change assessment, pediatric MRI

Procedures

• Phase I: Register Rigid/Affine

1. open Registration : BrainsFit module (presets: BRAINSfit_Xf1 or _Xf2
   1. Input Parameters:
      1. Fixed: "Autism_T1_2yrs"
      2. Moving: "Autism_T1_4yrs"
   2. Registration Phases:
      1. select/check Include Rigid registration phase , Include Scale Versor 3D , Include Affine, Include BSpline
   3. Output Settings
      1. select a new "Slicer BSpline Transform", rename to "Xf3_Affine+BSpline" or similar "
      2. select a new volume "Output Image Volume, rename to "Autism_T1_4yrs_Xf3", indicating that this is the result volume after being resampled with the Xf3 transform.
      3. Output Image Pixel Type: check "ushort". As a general rule, match the datatype of the input image, unless specific reason demands otherwise (e.g. you wish to avoid rounding of interpolation effects). The "float" datatype is 4-bytes per pixel and can produce unnecessary large files.
   4. Registration Parameters:
      1. increase Number Of Samples to 300,000
   5. Registration Parameters: set Number Of Grid Subdivisions to 5,5,5
   6. Leave all other settings at default
   7. click Apply

Registration Results

baseline and follow-up before registration (click to enlarge)
after affine alignment. Note the residual shape differences (click to enlarge)
after nonrigid BSpline registration (click to enlarge)
| visualization of the nonrigid deformation component only