Documentation/4.6/Extensions/OpenCAD
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Introduction and Acknowledgements
This work is supported by NA-MIC, NCIGT, and the Slicer Community. | |||||||
This project is supported by P41 RR019703/RR/NCRR NIH HHS/United States, P01 CA067165/CA/NCI NIH HHS/United States and P41 EB015898/EB/NIBIB NIH HHS/United States |
Modules
- SegmentCAD: Tumor Segmentation from DCE-MRI
- HeterogeneityCAD: Feature Extraction toolbox for image heterogeneity analysis
Extension Description
- The SegmentCAD module is designed to segment tumors from DCE-MRI datasets which include a pre-contrast image and post-contrast images at different time points.
- SegmentCAD uses blackbox methods to calculate the wash-in and wash-out slopes from the time-intensity curves.
- The segmentation output is a Label Map with red, yellow, and blue colors respectively identifying washout (Type III), plateau (Type II), and persistent (Type I) voxels.
- The HeterogeneityCAD module is an extensible, image feature extraction toolbox primarily to quantify the heterogeneity of tumor images and their label maps.
- Metrics have been implemented from a variety of feature classes including:
- First-Order/Histogram statistics
- Morphology/Shape measures and Geometrical (4D Extrusion) measures
- Renyi/Fractal dimensions
- Texture features computed from Gray-Level Co-occurrence Matrices (GLCM) and from Gray-Level Run Length matrices (GLRL)
- Metrics have been implemented from a variety of feature classes including:
Tutorials
- SegmentCAD
Data sets
- SegmentCAD
- HeterogeneityCAD
Quick Instructions for Use
- SegmentCAD (Click link for detailed description)
- Select the pre-contrast volume
- Select the first post-contrast volume
- Select the second post-contrast volume
- Select the third post-contrast volume
- Select the fourth post-contrast volume
- Create or select a label map volume node to represent the output of the segmentation
- Click "Apply OpenCAD Segmentation"
- HeterogeneityCAD (Click link for detailed description)
- Add an image or parameter map (.nrrd file) to the Nodes List
- Select a corresponding segmentation label map to use as ROI
- Click "Apply HeterogeneityCAD"
Similar Modules
- SegmentCAD:
- HeterogeneityCAD:
- LabelStatistics
References
- J. Jayender, E. Gombos, S. Chikarmane, D. Dabydeen, F. A. Jolesz, and K. G. Vosburgh, “Statistical Learning Algorithm for In-situ and Invasive Breast Carcinoma Segmentation”, Journal of Computerized Medical Imaging and Graphics, vol. 37, no. 4, pp. 281-292, 2013
- J. Jayender, S. A. Chikarmane, F. A. Jolesz and E. Gombos, “Automatic Segmentation of Invasive Breast Carcinomas from DCE-MRI using Time Series Analysis”, Journal of MRI, Article first published online 23 September 2013, doi: 10.1002/jmri.24394
- J. Jayender, K.G. Vosburgh, E. Gombos, A. Ashraf, D. Kontos, S.C. Gavenonis, F. A. Jolesz and K. Pohl , “Automatic Segmentation of Breast Carcinomas from DCE-MRI using a Statistical Learning Algorithm”, IEEE International Symposium on Biomedical Imaging, pp. 122-125, 2012.
- J. Jayender, D.T. Ruan, V. Narayan, N. Agrawal, F. A. Jolesz and H. Mamata, “Segmentation of Parathyroid Tumors from DCE-MRI using Linear Dynamic System Analysis”, IEEE International Symposium on Biomedical Imaging, 2013.
- J. Jayender, J. Jagannathan, S.Chikarmane, C.P.Raut and F.A. Jolesz, “Computer-Aided Diagnosis of Breast Angiosarcoma: Results in 14 cases”, Quantitative Medical Imaging Symposium, 2013 (invited paper).
- HJWL Aerts, ER Velazquez, RTH Leijenaar, et al., "Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach", vol. 5, Nat Communication, 2014.
Information for Developers
Source code: https://github.com/vnarayan13/Slicer-OpenCAD