Documentation/4.10/Extensions/LesionSimulator

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Introduction and Acknowledgements

This work was partially funded by CAPES and CNPq, a Brazillian Agencies. Information on CAPES can be obtained on the CAPES website and CNPq website. Authors: Antonio Carlos da S. Senra Filho and Fabrício Henrique Simozo, CSIM Laboratory (University of Sao Paulo, Department of Computing and Mathematics) Contacts: Antonio Carlos da S. Senra Filho <email>acsenrafilho@usp.br</email> - Fabrício Henrique Simozo <email>fsimozo@gmail.com</email>

CSIM Laboratory   University of Sao Paulo   CNPq Brazil   CAPES Brazil

Extension Description

This extension offers a set of tools for brain lesion simulation, based on MRI images. At the moment, the module MS Lesion Simulator is available, where it can simulate both baseline scan lesion volumes (given a lesion load) and longitudinal image simulations. In summary, a statistical lesion database is generated based on a set of manual lesion mark-ups, being non-linearly registered to MNI152 space (isotropic 1mm of voxel resolution), and a local contrast ratio is applied on each imaging modality provided by the user. Using a small set of parameters (lesion load, lesion homogeneity, lesion intensity independence and lesion variability), it is possible to generate a broad range of MS lesions patterns in multimodal MRI imaging techniques (at moment, T1, T2, T2-FLAIR, PD, DTI-FA and DTI-ADC images are provided). For more details about this project, please see the original paper.

Modules

• MS Lesion Simulator

Use Cases

Most frequently used for these scenarios:

• Use Case 1: Simulate different anatomical/clinical MS lesions patterns on healthy individuals MRI images
  • In the baseline scan approach, it is offered a simulation procedure where a determined lesion load is reconstructed using subject-specific anatomical features, resulting in a realistic MS lesion load simulation.
• Use Case 2: Simulate longitudinal MS lesion progression on clinical healthy individuals MRI images
  • Another important issue in Multiple Sclerosis diagnosis is the lesion progression, where drive the therapeutic strategy by the health professionals. In this case, an automatic segmentation approach could be optimally adjusted for the time progression presented in a exam series.

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  MS lesion simulation with 2mL lesion load

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  MS lesion simulation with 5mL lesion load

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  MS lesion simulation with 40mL lesion load

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  A 3D reconstruction of 2mL, 5mL and 40mL lesion loads showing that each lesion pattern is independent of each other

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  T1 weighted MRI brain in axial orientation (provided by the ICBM-MNI152 non linear brain template)

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  The same MNI152 template with 40mL lesion load simulated lesions (axial orientation)

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  T1 weighted MRI brain in sagittal orientation (provided by the ICBM-MNI152 non linear brain template)

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  The same MNI152 template with 40mL lesion load simulated lesions (sagittal orientation)

Tutorials

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  How to simulate T1 hypointense Multiple Sclerosis lesions

Similar Extensions

N/A

References

• Senra Filho, A. C. da S., Simozo, F. H., dos Santos, A. C., & Junior, L. O. M. (2019). Multiple Sclerosis multimodal lesion simulation tool (MS-MIST). Biomedical Physics & Engineering Express, 5(3), 035003. https://doi.org/10.1088/2057-1976/ab08fc

Feel free to enter in contact with the authors to request a private copy of the above paper.

Information for Developers

Repositories:

• Source code: GitHub repository
• Issue tracker: open issues and enhancement requests