Documentation/4.1/Modules/PkModeling

Introduction and Acknowledgements

Extension: PkModeling Acknowledgments: This work is part of the National Alliance for Medical Image Computing (NAMIC), funded by the National Institutes of Health through the NIH Roadmap for Medical Research. Implementation of the pharmacokinetics modeling was contributed by Yingxuan Zhu and Jim Miller from GE Research. Author: Yingxuan Zhu, Jim Miller (GE) Contact: Yingxuan Zhu, <email>zhuyi@ge.com</email>

GE Global Research   National Alliance for Medical Image Computing (NA-MIC)

Module Description

PkModeling (Pharmacokinetics Modeling) is to calculate the quantitative parameters from DCE-MRI images. The two major parts of it are: Convert signal intensities to concentration values. The concentration values will be used to calculate quantitative parameters. Calculate quantitative parameters from concentration values. These parameters include: Ktrans volume transfer constant between blood plasma and EES (extracellular-extravascular space) at each voxel Ve fractional volume for extracellular space at each voxel MaxSlope maximum slope in the time series curve of each voxel AUC area under the curve of each voxel, measured from bolus arrival time to the end time of interval, normalized by the AUC of the AIF

Panels and their use

PkModeling

IO Input: 4D DCE-MRI data in nrrd; 3D mask in nrrd, showing the location of arterial input function. Output: 4 volumes in nrrd, showing the maps of quantitative parameters. These parameters are ktrans, ve, maximum slope, and area under the curve (AUC). Parameters PkModeling: T1 Blood Value T1 Tissue Value Relaxivity Value Hematocrit Value AUC Time Interval Value: Time interval for AUC calculation Acquisition: TR Value: Repetition time, TE Value: Echo time, FA Value: Flip angle, Time Axis: Time series.

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• Documentation/4.1/Modules/MultiVolumeExplorer
• Documentation/4.1/Modules/MultiVolumeImporter

References

• Knopp MV, Giesel FL, Marcos H et al: Dynamic contrast-enhanced magnetic resonance imaging in oncology. Top Magn Reson Imaging, 2001; 12:301-308.
• Rijpkema M, Kaanders JHAM, Joosten FBM et al: Method for quantitative mapping of dynamic MRI contrast agent uptake in human tumors. J Magn Reson Imaging 2001; 14:457-463.