Slicer3:UIDesign:WorkingProblems:BCAnalysis:Volumetric

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Volumetric Tumor Analysis for Breast Cancer

Goal

Goal is to accommodate basic RECIST assessment for breast cancer (Response Evaluation Criteria In Solid Tumors). (RECIST is a set of published rules that define when cancer patients improve ("respond"), stay the same ("stable") or worsen ("progression") during treatments).

• Determine features that currently exist in Slicer
• Develop features that don't
• Provide a framework that knits features together in a comfortable workflow.

Linear Measurements

• Scroll through baseline
• Find the tumor's longest diameter (no reformat, just on orig acquisition)
• Measure the longest diameter D1(t1)
• Measure the orthogonal diameter D2(t1)
• If there are multiple tumors, measure both diams in each tumor and sum to get relative D1(t1) and relative D2(t1)
• Perform same measurements D1(t2) and D2(t2)
• Specific results to report:
  • Percent change
  • Absolute change
  • Question: units for these values -- mm^2?

Volume Measurements

• Scroll through dataset and determine tumor with largest diameter.
• Segment largest diameter tumor in baseline Question: multiple tumors ok?
  • Manual or automatic segmentation OK
• Segment tumor in followup Questions: Must be same tumor, or largest diameter in followup? multiple tumors ok?
  • Manual or automatic segmentation OK -- but use same method
• Measure:
  • Volume(t1) and Volume(t2) Question: which is preferred, mm^3 or cc?
  • Relative % difference
  • Absolute change (same units as above)