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| | + | #REDIRECT [[Documentation/4.2/Modules/PkModeling]] |
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| − | {{documentation/{{documentation/version}}/module-header}} | + | {{documentation/{{documentation/version}}/extension-footer}} |
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| − | {{documentation/{{documentation/version}}/module-section|Introduction and Acknowledgements}}
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| − | {{documentation/{{documentation/version}}/module-introduction-start|{{documentation/modulename}}}}
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| − | Extension: [[Documentation/{{documentation/version}}/Extensions/PkModeling|PkModeling]]<br>
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| − | Acknowledgments:
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| − | This work is part of the National Alliance for Medical Image Computing (NA-MIC), funded by the National Institutes of Health through the NIH Roadmap for Medical Research.<br>
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| − | Implementation of the pharmacokinetics modeling was contributed by Yingxuan Zhu and Jim Miller from GE Research.<br>
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| − | Author: Yingxuan Zhu, Jim Miller ({{collaborator|name|ge}})<br>
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| − | Contact: Yingxuan Zhu, <email>zhuyi@ge.com</email><br>
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| − | {{documentation/{{documentation/version}}/module-section|Module Description}}
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| − | {|
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| − | PkModeling (Pharmacokinetics Modeling) calculates quantitative parameters from Dynamic Contrast Enhanced DCE-MRI images. This module performs two operations:
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| − | # Converts signal intensities to concentration values. The concentration values are used to calculate quantitative parameters.
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| − | # Calculates quantitative parameters from concentration values. These parameters include:
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| − | ;Ktrans: Volume transfer constant between blood plasma and EES (extracellular-extravascular space) at each voxel
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| − | ;Ve: Fractional volume for extracellular space at each voxel
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| − | ;MaxSlope: Maximum slope in the time series curve of each voxel
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| − | ;AUC: Area under the curve of each voxel, measured from bolus arrival time to the end time of interval, normalized by the AUC of the AIF
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| − | {{documentation/{{documentation/version}}/module-section|Use Cases}}
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| − | {{documentation/{{documentation/version}}/module-section|Tutorials}}
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| − | {{documentation/{{documentation/version}}/module-section|Panels and their use}}
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| − | {|
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| − | |[[Image:PkModelingUI061912.png|thumb|340px|PkModeling]]
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| − | * '''IO'''
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| − | ** '''Input:''' 4D DCE-MRI data; 3D mask showing the location of the arterial input function.
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| − | ** '''Output:''' 4 volumes showing the maps of quantitative parameters: ktrans, ve, maximum slope, and area under the curve (AUC).
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| − | * '''Parameters'''
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| − | ** '''PkModeling''':
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| − | *** T1 Blood Value
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| − | *** T1 Tissue Value
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| − | *** Relaxivity Value
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| − | *** Hematocrit Value. Volume percentage of red blood cells in blood.
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| − | *** AUC Time Interval Value: Time interval for AUC calculation
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| − | ** '''Acquisition''':
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| − | *** TR Value: Repetition time,
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| − | *** TE Value: Echo time,
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| − | *** FA Value: Flip angle,
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| − | *** Time Axis: Time series.
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| − | |}
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| − | {{documentation/{{documentation/version}}/module-section|Similar Modules}}
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| − | * [[Documentation/{{documentation/version}}/Modules/MultiVolumeExplorer|MultiVolumeExplorer]]
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| − | * [[Documentation/{{documentation/version}}/Modules/MultiVolumeImporter|MultiVolumeImporter]]
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| − | {{documentation/{{documentation/version}}/module-section|References}}
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| − | * Knopp MV, Giesel FL, Marcos H et al: Dynamic contrast-enhanced magnetic resonance imaging in oncology. Top Magn Reson Imaging, 2001; 12:301-308.
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| − | * Rijpkema M, Kaanders JHAM, Joosten FBM et al: Method for quantitative mapping of dynamic MRI contrast agent uptake in human tumors. J Magn Reson Imaging 2001; 14:457-463.
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| − | {{documentation/{{documentation/version}}/module-section|Information for Developers}}
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| − | {{documentation/{{documentation/version}}/module-developerinfo}}
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| − | {{documentation/{{documentation/version}}/module-footer}}
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| − | [[Category:Documentation/{{documentation/version}}/Modules/Quantification]]
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